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Ovariectomy-induced osteoporosis model
- Test system: Cynomolgus monkey and rat
- Evaluation parameters: Bone density measured by DXA (Hologic Discovery
A) and pQCT (Norland Medical Systems, Inc, XCT3000), bone metabolic marker,
strength, and histomorphometry (outsourcing)
Collagen-induced arthritis model
- Test system: Cynomolgus monkey
- Evaluation parameters: General condition and swelling scores, X-ray examination,
- bone metabolic marker, anti-collagen antibody titer, cytokine, and histopathology
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